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Adavivint (SM04690)
Adavivint (SM04690,Lorecivivint) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. It is ?150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular as
Gigantol
Gigantol是一種來自幾種藥用蘭花的聯(lián)芐基化合物。Gigantol對癌癥有潛在治療價值。Gigantol是Wnt/β-catenin通路的抑制劑。
KY1220
KY1220 is a small molecule that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 reporter cells.
DK419
DK419 是一種有效、可口服的 Wnt/β-catenin 信號通路抑制劑,IC50 值為 0.19 μM。DK419 能降低 Axin2,β-catenin,c-Myc,Cyclin D1 和 Survivin 能夠改變細胞內耗氧率,誘導 pAMPK 的產生。
Pyrvinium pamoate (Pyrvinium embonate)
An anthelmintic and anticancer agent
JW 67
JW 67 抑制經典 Wnt 信號傳導,IC50 為 1.17μM。 JW 67 影響由 β-catenin/GSK-3β/AXIN/APC/CK1 組成的多蛋白復合物,該復合物迅速降低活性 β-catenin,隨后下調 Wn\u200b\u200bt 靶基因。 JW 67 還抑制結直腸癌細胞的生長。
Foxy-5
A Wnt5a peptide mimetic
GNF-6231
GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.
IWP 4
An inhibitor of Wnt production
IWP-2
EMT inhibitor-1
EMTinhibitor-1是Hippo,TGF-β和Wnt信號通路的抑制劑,并擁有抗腫瘤活性。
Wnt/β-catenin agonist 1
Wnt/β-catenin agonist 1 (compound 3f) 是 Wnt/β-catenin 信號通路的一個激動劑,EC50 值為 0.27 μM。
HLY78
A positive modulator of Wnt signaling
L-Quebrachitol
L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associ
Methyl vanillate
Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.
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