粉色视频高清下载版_久久夜色撩人精品国产av._东北老熟妇白浆大屁股流白浆_国产精品爽爽v?吃奶在线观看_国产亚洲精品美女视频_性生交大片免费一级_在线看免费无码AV丝袜_日本性高潮视频

全部分類(lèi)

Doxorubicin(Adriamycin;游離阿霉素)

Topo II inhibitor,immunosuppresive antineoplastic antibiotic

此產(chǎn)品僅用于科學(xué)研究，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

庫(kù)存: 現(xiàn)貨

可選規(guī)格

包裝

價(jià)格

促銷(xiāo)價(jià)

數(shù)量
10mg

￥750.00

350.00

- +
25mg

￥1000.00

450.00

- +
100mg

￥1875.00

1000.00

- +

已選 0 種 0 瓶

金額: ￥0.00

首頁(yè) 收藏

貨號(hào): ajci18230
CAS: 23214-92-8
別名: 阿霉素;多柔比星;羥柔紅霉素;羥正定霉素;亞法里亞霉素;羥基柔紅霉素;羥基紅比霉素;多柔比星雜質(zhì);阿霉素游離態(tài)
分子式: C27H29NO11
分子量: 543.52
純度: ＞98%
溶解度: Soluble in DMSO；Soluble in methanol
儲(chǔ)存: Store at -20°C
庫(kù)存: 現(xiàn)貨

Background

Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin intercalates into DNA double strand and inhibits the progression of DNA topoisomerase II, stopping replication process. [2] Doxorubicin also induces histone eviction from open chromatin, causing DNA damage and epigenetic deregulation. [3]

Doxorubicin is administrated intravenously. Approximately 75% of doxorubicin and its metabolites bind to plasma protein. Doxorubicin does not cross blood brain barrier. 50% of the drug is eliminated unchanged from the body mainly though bile excretion. The remaining undergoes one-electron reduction, two-electron reduction, and deglycosidation. The major metabolite is a potent membrane ion pump inhibitor, which is associated with cardiomyopathy. [4]

參考文獻(xiàn):
[1]Brayfield, A, ed. (2013). Doxorubicin. Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 15 April 2014.
[2]Pommier Y., et al. (2010). DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chemistry & Biology 17 (5): 421–433.
[3]Pang, B., et al. (2013). Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin. Nature Communications 4 (5): 1908
[4]Boucek RJ., et al. (1987). The major metabolite of doxorubicin is a potent inhibitor of membrane-associated ion pumps. A correlative study of cardiac muscle with isolated membrane fractions. J of Biol Chem 262: 15851-15856.